Constance R. Chu, MD
Professor and Vice Chair
Department of Orthopedic Surgery
Joint Preservation Center
VA Palo Alto
From the March issue: Patient-Reported Outcomes and Knee Mechanics Correlate With Patellofemoral Deep Cartilage UTE-T2* 2 Years After Anterior Cruciate Ligament Reconstruction
Podcast: Listen to Dr. Chu discuss her article in the March issue.
Dr. Constance R. Chu is Professor and Vice Chair Research, in the Department of Orthopedic Surgery at Stanford University and Director of the Joint Preservation Center at the VA Palo Alto. She is a surgeon-scientist who has been awarded more than $20 million in federal research grants from the National Institutes of Health (NIH), the Veterans Administration (VA), and the Department of Defense (DOD) for innovative bench to bedside work in regenerative medicine, quantitative MRI, and the prevention of osteoarthritis (OA). The central goal of her research program is to transform the clinical approach to osteoarthritis from palliation to prevention. Dr. Chu’s work has been recognized by more than 30 professional honors to include two Kappa Delta Awards, considered to be the highest research honor in Orthopedic Surgery. Her clinical practice focuses on the knee: primarily reconstruction and restoration of the anterior cruciate ligament (ACL), menisci and cartilage.
Dr. Chu graduated from the U.S. Military Academy at West Point. Following distinguished military service, she earned her medical degree from Harvard Medical School. She was previously the Albert Ferguson Endowed Chair in Orthopedics and Bioengineering at the University of Pittsburgh where she was recognized as a Pittsburgh “Top Doctor”, as well as on Becker’s list of Top Knee Surgeons in the United States. Dr. Chu is alumnus of the American Orthopedic Association American, British, Canadian (ABC) and the American Orthopedic Society for Sports Medicine (AOSSM) Traveling Fellowships. She is also past President of the Forum Sports Focus Group, past Chair of the AOSSM Research Council, and Co-Chair of the AOSSM Diversity Task Force.
Selected Other Published Work
Chu CR, Williams AA. Quantitative MRI UTE-T2* and T2* Show Progressive and Continued Graft Maturation Over 2 Years in Human Patients After Anterior Cruciate Ligament Reconstruction. Orthopaedic Journal of Sports Medicine. 2019 Aug;7(8):2325967119863056 6693027.
Titchenal MR, Williams AA, Chehab EF, et al, Chu CR. Cartilage Subsurface Changes to Magnetic Resonance Imaging UTE-T2* 2 Years After Anterior Cruciate Ligament Reconstruction Correlate With Walking Mechanics Associated With Knee Osteoarthritis. The American Journal of Sports Medicine. 2018;46(3):565-572. doi:10.1177/0363546517743969
Xiong G, Lingampalli N, Koltsov JCB, et al, Chu CR. Men and Women Differ in the Biochemical Composition of Platelet-Rich Plasma. The American Journal of Sports Medicine. 2018;46(2):409-419. doi:10.1177/0363546517740845
Titchenal MR, Chu CR, Erhart-Hledik JC, Andriacchi TP. Early Changes in Knee Center of Rotation During Walking After Anterior Cruciate Ligament Reconstruction Correlate With Later Changes in Patient-Reported Outcomes. The American Journal of Sports Medicine. 2017;45(4):915-921. doi:10.1177/0363546516673835. Winner, 2016 AOSSM O’Donoghue Sports Injury Award.
Chu CR, Williams AA, West RV, et al. Quantitative Magnetic Resonance Imaging UTE-T2* Mapping of Cartilage and Meniscus Healing After Anatomic Anterior Cruciate Ligament Reconstruction. The American Journal of Sports Medicine. 2014;42(8):1847-1856. doi:10.1177/0363546514532227
Braun HJ, Kim HJ, Chu CR, Dragoo JL. The Effect of Platelet-Rich Plasma Formulations and Blood Products on Human Synoviocytes: Implications for Intra-articular Injury and Therapy. The American Journal of Sports Medicine. 2014;42(5):1204-1210. doi:10.1177/0363546514525593
Chu CR, Beynnon BD, Dragoo JL, et al. The Feasibility of Randomized Controlled Trials for Early Arthritis Therapies (EARTH) Involving Acute Anterior Cruciate Ligament Tear Cohorts. The American Journal of Sports Medicine. 2012;40(11):2648-2652. doi:10.1177/0363546512465409
Chu CR, Beynnon BD, Buckwalter JA, et al. Closing the Gap Between Bench and Bedside Research for Early Arthritis Therapies (EARTH): Report From the AOSSM/NIH U-13 Post–Joint Injury Osteoarthritis Conference II. The American Journal of Sports Medicine. 2011;39(7):1569-1578. doi:10.1177/0363546511411654
Szczodry M, Coyle CH, Kramer SJ, Smolinski P, Chu CR. Progressive Chondrocyte Death After Impact Injury Indicates a Need for Chondroprotective Therapy. The American Journal of Sports Medicine. 2009;37(12):2318-2322. doi:10.1177/0363546509348840
Karpie JC, Chu CR. Lidocaine Exhibits Dose- and Time-Dependent Cytotoxic Effects on Bovine Articular Chondrocytes in Vitro. The American Journal of Sports Medicine. 2007;35(10):1622-1627. doi:10.1177/0363546507304719
Chu CR, Lin D, Geisler JL, Chu CT, Fu FH, Pan Y. Arthroscopic Microscopy of Articular Cartilage Using Optical Coherence Tomography. The American Journal of Sports Medicine. 2004;32(3):699-709. doi:10.1177/0363546503261736