May Featured Author

Murray in the lab 2017
Martha Murray, MD
Professor of Orthopaedic Surgery
Boston Children’s Hospital
Harvard Medical School

From the May issue: Bridge-Enhanced Anterior Cruciate Ligament Repair Is Not Inferior to Autograft Anterior Cruciate Ligament Reconstruction at 2 Years: Results of a Prospective Randomized Clinical Trial

Podcast: Listen to Dr. Murray discuss her article in the May issue.

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Martha Murray, MD, is a Professor of Orthopaedic Surgery at Harvard Medical School.  She has developed a novel technique of Bridge-Enhanced™ ACL repair which utilizes a bio-engineered scaffold to stimulate healing of the ligament instead of the traditional harvesting of a graft of tendon to replace the torn ACL and translated it from the lab to the operating room with grant funding from various sources, including the NIH and NFL Players association.  She has founded a company, MIACH Orthopaedics, to manufacture the scaffold.  She has 9 issued patents and over 100 peer-reviewed publications around the development of this technology, including the most cited article in the Orthopaedic Journal of Sports Medicine.  She has won the AAOS Kappa Delta Award, been named one of Fast Company’s Top 100 Most Creative People in Business, been featured in Stephen Hawking’s Brave New World Series and been featured in a video on Tech Insider that garnered over 65 million views.  Martha has a BS in Mechanical Engineering from the University of Delaware, a MS in Materials Science and Engineering from Stanford, and received her MD from the University of Pennsylvania prior to completing residencies and fellowships at Harvard Medical School.

Selected Other Published Work

Murray MM, Weiler A, Spindler KP. Interspecies variation in the fibroblast distribution of the anterior cruciate ligament. Am. J. Sports Med., 2004; 32:1484-1491.

Fleming BC, Spindler KP, Palmer M, Magarian E, Murray MMCollagen-platelet composites improve the biomechanical properties of healing anterior cruciate ligament grafts in a porcine model. Am J Sports Med., 2009 Aug; 37(8):1554-63. PMCID: PMC2796133.

Joshi SM, Mastrangelo AN, Fleming BC, Murray MM. Collagen-platelet composite enhances biomechanical and histologic healing of the anterior cruciate ligament. Am. J. Sports Med., 2009 Dec; 37(12):2401-10.  PMCID: PMC2856313.

Magarian EM, Fleming BC, Harrison SL, Mastrangelo AN, Badger G,  Murray MMDelay of 2 or 6 weeks adversely affects the functional outcome of augmented primary repair of the porcine anterior cruciate ligament.  Am. J. Sports Med., 2010 Dec; 38(12): 2528-34. PMCID: PMC2996471.

Harrison S, Vavken P, Kevy S, Jacobson M, Zurakowski D, Murray MM.  Platelet activation by collagen provides sustained release of anabolic cytokines. Am J Sports Med. 2011, Apr 39(4):729-34.  PMCID: PMC3176726.

Biercevicz A, Miranda DL, Machan JT, Murray MM, Fleming BC. In situ non-invasive T2*-weighted MRI derived parameters determine ex vivo structural properties of an anterior cruciate ligament reconstruction or bio-enhanced primary repair in a porcine model. Am J Sports Med. 2013 Mar;41(3):560-6. PMCID: PMC3593999.

Murray MM,  Fleming BC. Use of a bioactive scaffold to stimulate anterior cruciate ligament healing also minimizes post-traumatic osteoarthritis after surgery. Am J Sports Med. 2013 Aug;41(8):1762-70. PMCID: PMC3735821.

Proffen BL, Vavken P, Haslauer CM, Fleming BC, Harris CE, Machan JT, Murray MMAddition of autologous mesenchymal stem cells to whole blood for bioenhanced anterior cruciate ligament repair has no benefit in the porcine model. Am J Sports Med. 2015 Feb;43(2):320-30. PMCID: PMC4511104.

Kiapour AM, Fleming BC, Proffen BL, Murray MMSex influences the biomechanical outcomes of anterior cruciate ligament reconstruction in a pre-clinical large animal model. Am J Sports Med. 2015 Jul;43(7):1623-31. PMCID: PMC4490080.

Kiapour, AM, Ecklund, KE, Murray, MM, BEAR Trial Team, Flutie B, Freiberger, C, Henderson, R, Kramer, D, Micheli LJ, Yen YM, Fleming BC. Changes in cross sectional area and signal intensity of healing anterior cruciate ligaments and grafts in the first 2 years after surgery. AJSM, 2019 Jul; 47(8):1831-1843. PMID 31166701.

Murray MM, Kiapour AM, Kalish LA, Ecklund K; BEAR Trial Team, Freiberger C, Henderson R, Kramer D, Micheli LJ, Yen YM, Fleming BC. Predictors of Healing Ligament Size and Magnetic Resonance Signal Intensity at 6 Months After Bridge-Enhanced Anterior Cruciate Ligament Repair. Am J Sports Med. 2019 May;47(6):1361-1369. doi: 10.1177/0363546519836087. Epub 2019 Apr 15.  PMID: 30986539.

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