August Featured Author

Constance R. Chu, MD

Department of Orthopaedic Surgery, Stanford University

From the August Issue: Quantitative Magnetic Resonance Imaging UTE-T2^* Mapping of Cartilage and Meniscus Healing After Anatomic Anterior Cruciate Ligament Reconstruction.

Podcast: Listen to Dr. Chu discuss her article in the August issue.

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Dr. Constance R. Chu is Professor and Vice Chair Research, in the Department of Orthopedic Surgery at Stanford University. She is also Director of the Joint Preservation Center and Chief of Sports Medicine at the VA Palo Alto. Previously, she was the Albert Ferguson Professor of Orthopaedic Surgery at the University of Pittsburgh. She is a clinician-­‐scientist who is both principal investigator of several projects funded by the National Institutes of Health and who has been recognized as a Castle-­‐Connelly/US News and World Report “Top Doctor” in Orthopedic Surgery as well as on Becker’s list of 125 Top Knee Surgeons in the United States. Her clinical practice focuses on the knee: primarily restoration and reconstruction of the ACL, menisci and cartilage. She graduated from the U.S. Military Academy at West Point and earned her medical degree from Harvard Medical School.

As Director of the multi-­‐disciplinary Joint Preservation Center structured to seamlessly integrate basic, translational and clinical research with clinical practice, Dr. Chu developed the center to advance the concept of early diagnosis and treatment of cartilage injury and degeneration as a strategy to delay or prevent the onset of disabling osteoarthritis. Towards this end, she is leading innovative translational research from bench to bedside in three main areas: quantitative imaging and biomarker development for early diagnosis and staging of joint and cartilage injury and degeneration; cartilage tissue engineering and stem cell based cartilage repair; and molecular and biological therapies for joint restoration and joint rejuvenation. Her research efforts have led to more than 30 professional awards and honors to include a Kappa Delta Award, considered to be the highest research honor in Orthopedic Surgery.

Dr. Chu also regularly holds leadership and committee positions in major professional organizations such as the American Association of Orthopedic Surgeons (AAOS) and the American Orthopedic Association (AOA). In her subspecialty of Orthopedic Sports Medicine, she is a past President of the Forum Sports Focus Group, a member of the Herodicus Society of leaders in Sports Medicine, and immediate past Chair of the American Orthopedic Society for Sports Medicine (AOSSM) Research Council. She is alumnus of the highly AOA American, British, Canadian (ABC) Traveling Fellowship and the AOSSM Traveling Fellowship, opportunities enacted to recognize and promote the careers of emerging leaders in orthopedic surgery and orthopedic sports medicine, respectively.

Selected Other Published Works in AJSM

The Effect of Platelet-Rich Plasma Formulations and Blood Products on Human Synoviocytes: Implications for Intra-articular Injury and Therapy Am J Sports Med May 2014 42 1204-1210; published online before print March 14, 2014, doi:10.1177/0363546514525593

Progressive Chondrocyte Death After Impact Injury Indicates a Need for Chondroprotective Therapy Am J Sports Med December 2009 37 2318-2322; published online before print October 28, 2009, doi:10.1177/0363546509348840

 Lidocaine Exhibits Dose- and Time-Dependent Cytotoxic Effects on Bovine Articular Chondrocytes In Vitro Am J Sports Med October 2007 35 1621-1627; published online before print July 30, 2007, doi:10.1177/0363546507304719

Arthroscopic Microscopy of Articular Cartilage Using Optical Coherence Tomography Am J Sports Med April 2004 32 699-709; published online before print March 11, 2004, doi:10.1177/0363546503261736

Recovery of Articular Cartilage Metabolism Following Thermal Stress Is Facilitated by IGF-1 and JNK Inhibitor Am J Sports Med January 2004 32 191-196; doi:10.1177/0363546503260743

 Recovery of Chondrocyte Metabolic Activity after Thermal Exposure Am J Sports Med May 2003 31 392-398